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INSTITUTE OF NEUROBIOLOGY
The Institute of Neurobiology of the University of Puerto Rico Medical Sciences Campus is an interdepartmental, interdisciplinary research facility. It is devoted to and equipped for the study of excitable cells and the neurobiology systems formed by them. In addition, the laboratory provides access to the rich fauna and flora which inhabit the littoral waters and the rain forests of Puerto Rico. All laboratory facilities are open to cellular neurobiologists and to research workers including physiologists, anatomists, biochemists, toxicologists, zoologists, and others, both from the University of Puerto Rico and visiting scientists from universities on the mainland and foreign countries.
Ongoing research includes studies of oscillating neuronal circuits in lobster ganglia, the interactions between neurons and glial cells in amphibians, excitation-contraction coupling in invertebrate muscle, establishment of synapses between identified neurons
in insects, gene expression in individual identified pyloric neurons in lobsters calcium signaling in muscle, the nature and neural control of ligament stiffening of the joints of
sea urchin spines, and the activity, synthesis and turnover of the sodium pump in vertebrates and invertebrates.

Retinal projection pathways responsible for the transmission of color information in the visual system, and the morphology of retinal cells that preferentially respond to certain colors are also under investigation. Molluscs are used to investigate the roles of
neuropeptides as signaling molecules in the mediation and modulation of behavior. The neurotoxic actions of compounds isolated from tropical marine organisms, some of which are implicated in the fish intoxication syndrome known as ciguatera, are also studied at the cellular level.

The Institute is housed in a building overlooking the Atlantic Ocean in Old San Juan. In addition to laboratories and equipment for experimental research in morphology, including electron microscopy and confocal microscopy, electrophysiology, tissue culture, imaging of intracellular ions by fluorescence methods, and neurochemistry. There are class and seminar rooms, staff offices, and workshops. Guest rooms and kitchen facilities are also available for visiting scientists.

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